Description

CAS NO. ******2 (Base) ******2 (Hydrochloride) ******1 (Mesylate) EINECS NO. ********5 FORMULA C*7H*9N3O�CH3SO3H MOL WT. **7.*7 PHYSICAL AND CHEMICAL PROPERTIES PHYSICAL STATE white to off-white crystalline powder MELTING POINT **7 - **8 C BOILING POINT SPECIFIC GRAVITY SOLUBILITY IN WATER Soluble APPLICATIONS Phentolamine is an adrenergic receptor antagonist and peripheral vasodilator. It is used to prevent and treat hypertension due to pheochromocytomain and to control cutaneous necrosis and sloughing when extravasation of norepinephrine. It is chemically described as m-[N-(*-lmidazolin**-ylmethyl)-p-toluidino] phenol or *-(N-[m-Hydroxyphenyl]-p- toluidinomethyl) imidazoline. Phentolamine Hydrochloride: the monohydrochloride salt of phentolamine; administered orally. Phentolamine Mesylate: the methanesulfonate salt of phentolamine; a white or off-white crystalline powder; freely soluble in water and in alcohol; slightly soluble in chloroform; melting point **8 C; administered intramuscularly and intravenously. SALES SPECIFICATION APPEARANCE white crystalline powder IDENTIFICATION Complies Test A,B ASSAY *9.0% min LOSS ON DRYING 1.0% max RELATED SUBSTANCE 0.5% max HEAVY METALS *0ppm max SULFATED ASH 0.1% max